Un-natural Amino Acids
Un-natural amino acids are challenging compounds to develop efficient routes of syntheses and yet are useful tools in drug discovery. We have developed expertise in the preparation of a range of alpha and N-substituted amino acids, with various protecting groups.
Chiral amino alcohols derived from amino acids are useful materials for installing enantioenriched functionality. We have developed expertise in processing amino acids to generate highly enantiopure amino-alcohols on large scale.
Amino acid N-Carboxy-Anhydrides (NCAs)
AA-NCAs are a widely used precursor for peptide synthesis. They’re simple in structure, however, the preparation on larger scale with high purity is a challenge. Raffles has tackled this challenge successfully. Note that many NCAs are unstable and so are typically made in response to an order, and delivered through a cold chain logistics delivery mode.